Police Scotland confirmed on Tuesday night that emergency works were needed due to a gas leak at the A75/A701 Bloomfield roundabout.
A four-way traffic light system was put in place in the early hours of Wednesday morning.
Gas distribution company SGN have stated the road should be back to normal by Saturday morning.
A SGN spokesman yesterday said: “We’re continuing our work under four-way temporary traffic lights at the A75/A701 Bloomfield Roundabout in Dumfries to carry out emergency repairs to our gas network.
“We’ve made good progress and have now completed repairs.
“We now need to restore the road surface to the required specifications before removing the temporary traffic lights.
“All going well, we hope to return the road to normal on Saturday morning.
“We’re aware this is a busy route for motorists and the disruption is causing delays.
“This is however a complex repair and our teams are working as quickly and safely as possible.”
Meanwhile, police have pleaded with the public to allow extra travel time and to expect delays. Drivers have experienced lengthy queues especially during peak travelling times and flocked to Facebook to air their frustrations.
One Dumfries resident said: “More than patience is needed. I sat for 40 minutes today before 2 pm not moving.
“I eventually turned around and the traffic was backed right up the main road and into Heathhall.”
Another added: “Avoid like the plague.”