Shepherd Chartered Surveyors have sold the former Farmfoods on Queensberry Street to pub firm Amber Taverns for an undisclosed sum.
The former retail unit will be converted into a new modern pub, with Amber looking to open in time for Christmas this year.
Sam Frankland, property director at Amber Taverns, said: “We look forward to bringing an Amber pub to Dumfries.
“We will invest around £600,000 in this building to create an attractive pub which we believe will appeal to a wide range of customers.
“We hope Dumfries will mirror the success of our recent opening in Paisley, which was our first trading site in Scotland.”
He added: ““We have started our development in Coatbridge on the former Post Office which is also due to open before Christmas, and we have other sites in legals in Scotland and will make further announcements soon.”
Fraser Carson, surveyor in Shepherd’s Dumfries office, added: “This purchase follows a number of recent restaurant and licensed trade openings in Dumfries town centre, where longstanding retail and office premises have been selected for change of use.
“We are delighted that Amber Taverns has purchased this property with the aim of refurbishing and converting it into the latest addition to its expanding portfolio of high standard community pubs.”
Amber Taverns have 147 public houses across England, Wales and Scotland.
