In the seven days up to yesterday, there were 426 new positive cases recorded locally.
And, as of yesterday, there were 24 people in hospital in Dumfries and Galloway as a result of the virus.
The most affected neighbourhoods in the last week were Lochmaben, Lockerbie, Troqueer, Thornhill and Collin, according to Public Health Scotland.
Commenting on the situation, director of public health Valerie White said: “We’ve seen an increase in the number of new covid cases that were recorded last week.
“However, overall the movement is still in the direction of a decline from the peak in late August– albeit a much slower one than we would like to see.
“Covid-19 is still present at higher levels than we would wish and it continues to impact on health, our public services and daily lives. We’re conscious that we’re heading into colder months when we know people will be spending more time indoors, and when we know we have the risk of higher rates.
“We’re also aware of the combined dangers posed by a possible increase in other respiratory illnesses.”
