Prices have gone up by 3.8 per cent for journeys on ScotRail services.
Subsequently, the cost of a season ticket between the two towns has increased by £52 a year, from £1400 to £1452.
Meanwhile, the cost of travelling from Dumfries to Glasgow on a season ticket has risen by £221, to £4848.
The changes have been slammed as ‘brutal’ by South Scotland MSP Colin Smyth.
He pointed out it’s the highest in a decade and said: “It is wildly reckless to hit passengers with this brutal rip-off fare rise while a cost of living crisis rages on.
“Slapping passengers with the biggest hike in a decade, months before ScotRail is taken into public hands is an utterly shameful start.
“The latest hike means peak prices on ScotRail services have risen by an eye watering 38 per cent since 2012.”
Meanwhile, a price hike is due in March on West Coast Mainline, East Coast Mainline and Transpennine Express services.