That was the estimate published this week by the National Records of Scotland (NRS) and based on mid 2018 statistics.
The average age of a local resident is 49 and there are 1457 people aged over 90 and 1248 under one.
The gender split is slightly in favour of women who number 76,469, while there are 72,321 men.
Between June 2017 and June 2018 there were 1257 births locally and 2047 deaths, which led to a drop in the population of 410 persons, or 0.3 per cent.
And in the last decade, since 2008, the region’s population has gone down by 1.5 per cent overall, or 2220 fewer residents.
However, there was inward migration to the area by 4020 people last year, compared to 3630 moving away.
Finally, the NRS estimate there are 23 people for every square kilometre of Dumfries and Galloway.