Emergency services, including firefighters, were called to the worst affected areas.
At one point residents in Annan tried to prevent flooding reaching their homes by scooping buckets of water from their front gardens by hand and then pouring it out on the road.
Firefighters brought in pumping equipment to help protect properties bordering the lower lying parts of Newington Park.
One householder knocked holes in a garden wall to release trapped flood water.
Other flooded routes included sections of Newington Road, Drummond Road, Rose Street and Butts Street, near the Spar Shop.
Some property occupiers used flood gates on their front doors, others shopping bags filled with sand while Dumfries and Galloway Council later delivered sandbags to the town.
Gardens, some with sheds, in areas to the north of the town centre suffered the most from the water and some homes were damaged.
By Saturday night a clear-up was underway, the full cost of what happened was being assessed and questions asked why the drainage infrastructure was unable to cope.
Police Scotland say that several roads were closed to through traffic for periods in Annan while at Eastriggs the worst effected streets were Pretoria Road and Delhi Road.